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Table 1 Computed growth coupling strength values for all strategies shown in Fig. 3. GCS values of the respective strain designs and number of reaction deletions are colored according to the GC classification of increasing GC strength from wGC (red), hGC (blue) to sGC (green). The values in bold mark the highest GCS among the GC strain designs from literature (D) as well as from gcOpt with a fixed growth rate μfix of 0.01 h−1 (A), 0.1 h−1 (B) and 0.25 h−1 (C), respectively. The MMF strain design is taken from [4]. All other designs in column D are taken from [20]

From: Determination of growth-coupling strategies and their underlying principles

μfix = 0.01 h–1 (A) μfix = 0.1 h–1 (B) μfix = 0.25 h–1 (C) Literature (D)
Design GCS Design GCS Design GCS Design GCS
WT -1.97 WT -1.97 WT -1.97 WT -1.97
1 KO -0.91 1 KO -1.91 1 KO -0.91 MMF 7 KO 0.27
2 KO 0.16 2 KO -1.87 2 KO 0.26 OK 7 KO No GC
3 KO 0.63 3 KO 0.40 3 KO 0.35 cMCS 4 KO -0.75
4 KO 0.58 4 KO 0.43 4 KO 0.31 RK 2 KO -1.83
5 KO 0.58 5 KO 0.45 5 KO 0.48 cMCS 5 KO 0.52