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Table 5 Classification rules identified by Logic Learning Machine applied to gene expression profiles in eight selected data sets for cancer diagnosis

From: Analyzing gene expression data for pediatric and adult cancer diagnosis using logic learning machine and standard supervised methods

Output

Condition 1

Condition 2

Condition 3

Covering

GDS4968

 Monoc. Gamm.

SNHG3_1 ≤ 9.28

SNORA14B ≤ 4.30

95.0%

 Monoc. Gamm.

Control_3389 ≤ 8.20

60.0%

 MM

THOP1 > 6.23

TARP_5 ≤ 6.71

85.4%

 MM

C22orf23 ≤ 5.20

FLJ20712 ≤ 3.14

26.8%

 Smold. MM

DNAJC7 > 8.13

IGK_2 ≤ 10.4561

DEK > 6.50

97.0%

 Smold. MM

HNRNPA1 > 6.44

51.5%

GDS4887

 HC

AQP7 ≤ 8.46

100%

 Non tumor

CLPX_1 > 11.4116

100%

GDS4794

 Normal cells

DSCC1_1 ≤ 110.1

100%

 SCLC

CBX3_1 > 2232.75

100%

GDS4762

 Breast cancer

FMN2 < = 116.32

100%

 Fibroblast

SHC4 > 52.20

100%

GDS4471

 Classic MB

EFHD2_1 > 3.87

LOC100132891 ≤ 4.37

88.3%

 Classic MB

TCL1A > 4.66

31.4%

 Other MB

LOC100132891 > 4.18

5.47 < ZMYM5_3 ≤ 6.17

 

76.0%

 Other MB

CHIAP2 > 3.38

ZNF212 ≤ 6.45

40.0%

GDS4296

 Colon cancer

KLK6 > 7.71

100%

 Melanoma

EDNRB > 5.72279

100%

 Non-SCLC

5.61 < TMEM51 ≤ 6.55

FAM177A1 > 8.27

LINC00936 > 5.59

100%

 Ovarian cancer

TMEM101 ≤ 6.15

85%

 Ovarian cancer

MEIS1_1 > 6.70

57.1%

 Renal cancer

LRRN4 > 4.69

APBB1IP_2 > 7.46

100%

GDS3952

 Benign diseasea

2.32 < IGHV7–81 ≤ 3.29

2.87 < BM983749 ≤ 4.06

LIM2 > 4.11

83.8%

 Benign diseasea

LCP2_1 > 9.07

ST8SIA2_1 ≤ 2.215

27.0%

 Ectopic cancers

ST3GAL1 > 6.55

PWWP2A > 6.18

100%

 Healthy controls

USMG5 > 11.85

90.3%

 Healthy controls

NUFIP2_1 > 8.81

41.9%

 Breast cancera

MKNK1 ≤ 3.91

227762_at ≤8.3

BF194770 > 2.385

80.4%

 Breast cancer

ZNF81 ≤ 2.99

MMAB_1 ≤ 4.095

29.4%

 Breast cancer

AU143882 > 4.57

21.6%

GDS3945

 Untreated controls

COQ10A < = 125.66

100%

 Renal cancer

COQ10A > 125.66

100%

  1. Monoc. Gamm. Monoclonal Gammopathy, MM Multiple Myeloma, Smold. MM Smoldering Multple Myeloma, SCLC Small Cell Lung Cancer, HC Hepatocellular Carcinoma, MB Medulloblastoma
  2. aClassification algorithm truncated to the first three rules with the highest covering