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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models

Fig. 1

Fanconi anemia curated map, based in the KEGG FA pathway. There are two protein complexes: RPA, composed of RPA1, RPA2, RPA3 and RPA4, and Core, composed of FANCM, FANCG, FANCL, FAAP100, FANCA, FANCB, UBE2T, STRA13, FANCC, FAAP24, HES1, FANCE, FANCF, BLM, RMI1, RMI2 and TOP3A. At the end of the effector nodes, whose names are taken for the circuits, a description of the main functionalities triggered by the signaling circuits can be found

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