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Table 2 Differential circuit activity in a comparison of healthy versus FA bone marrow cells. Circuits are named after their effector nodes (see Fig. 1)

From: Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models

CIRCUIT

Activation

Statistic

p-value

FDR adj. p-value

RAD51

UP

0.615

0.558

0.659

MLH1-PMS2

UP

2.400

0.016

0.067

REV3L

DOWN

−3.789

3.917 × 10−5

5.092 × 10− 4

RAD51C

DOWN

− 1.924

0.056

0.162

RPA*

UP

3.412

6.923 × 10−4

4.500 × 10−3

FANCM-STRA-FAAP24

UP

1.885

0.062

0.162

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BMC Bioinformatics

ISSN: 1471-2105

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