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Table 2 Differential circuit activity in a comparison of healthy versus FA bone marrow cells. Circuits are named after their effector nodes (see Fig. 1)

From: Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models

CIRCUIT Activation Statistic p-value FDR adj. p-value
RAD51 UP 0.615 0.558 0.659
MLH1-PMS2 UP 2.400 0.016 0.067
REV3L DOWN −3.789 3.917 × 10−5 5.092 × 10− 4
RAD51C DOWN − 1.924 0.056 0.162
RPA* UP 3.412 6.923 × 10−4 4.500 × 10−3
FANCM-STRA-FAAP24 UP 1.885 0.062 0.162