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Table 3 List of most relevant genes (relevance > 0.006) obtained by the model. Drug IDs in bold are approved for use according to DrugBank database

From: Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models

GENE NAME SYMBOL ENTREZ ID RELEVANCE TARGETING DRUGS (DrugBank ID)
NIMA related kinase 2 NEK2 4751 0.097324 DB07180, DB12010
DNA topoisomerase II alpha TOP2A 7153 0.078623 DB00276, DB00385, DB00444, DB00694, DB00773, DB00970, DB00997, DB01177, DB01179, DB01204, DB04576, DB04967, DB04975, DB04978, DB05022, DB05706, DB05920, DB06013, DB06263, DB06362, DB06420, DB06421
baculoviral IAP repeat containing 5 BIRC5 332 0.052406 DB04115, DB00206, DB05141
centromere protein E CENPE 1062 0.036961 DB06097
polo like kinase 1 PLK1 5347 0.036159 DB06897, DB06963, DB07789
cyclin dependent kinase 1 CDK1 983 0.022697 DB05037, DB06195
glutamate ionotropic receptor NMDA type subunit 1 GRIN1 2902 0.019528 DB01931, DB04620, DB05824, DB06741, DB09409, DB09481
cholinergic receptor nicotinic beta 2 subunit CHRNB2 1141 0.013228 DB05855
synaptosome associated protein 25 SNAP25 6616 0.012799 DB00083
enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2 2146 0.012543 DB12887, DB14581
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 MTHFD1 4522 0.012111 DB00116, DB02358, DB04322
thymidylate synthetase TYMS 7298 0.009462 DB00293, DB00322, DB00432, DB00440, DB00544, DB00642, DB01101, DB05116, DB05308, DB05457, DB07577, DB08478, DB08479, DB08734, DB09256
serpin family E member 1 SERPINE1 5054 0.009206 DB05254
cytochrome c oxidase subunit I COX1 4512 0.008027 DB09140
retinoic acid receptor alpha RARA 5914 0.007607 DB00523, DB00799, DB00982, DB04942, DB05785
sodium voltage-gated channel alpha subunit 2 SCN2A 6326 0.006728 DB13520
kinesin family member 11 KIF11 3832 0.006366 DB03996, DB04331, DB06040, DB07064, DB08032, DB08033, DB08037, DB08198, DB08239, DB08244, DB08246, DB08250