Table 8 Comparison of miRFA to other available tools for functional analysis of miRNAs
Feature | Tool | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
miRFA | miRCancerdb | multiMiR | RBiomirGS | MiRComb | miRLab | miRpath | miEAA | TAM | GeneTrail2 | ||
Platform | R/Web-based | R/Web-based | R | R | R | R | Web-based | Web-based | Web-based | Web-based | |
MiRNA input/expression | Mature miRNA | ✓ | ✓ | ✓ | ✓ | a | ✓ | ✓ | ✓ | ||
Precursor miRNA | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||
MiRNA target prediction database | Experimentally validated database(s) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
Target prediction database(s) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
Correlation analysis expression levels | mRNA expression | ✓ | ✓ | ✓ | ✓ | ||||||
Protein expression | ✓ | ✓ | |||||||||
Negative correlation | ✓ | ✓ | ✓ | ✓b | |||||||
Positive correlation | ✓ | ✓ | |||||||||
Functional enrichment | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
Disease-specific | ✓ | ✓ | ✓ | ✓ | |||||||
miRNA annotation c | ✓ | ✓ | ✓ | ||||||||