Fig. 5

Two parsimonious models for the EPO induced JAK2/STAT5 signalling pathway. Upper panel: Part of the EPO induced JAK2/STAT5 signalling pathway related to the synthesis of CISH mRNA [13]. Dash-dotted arrows denote a transcription, solid arrows a state transition. Boxes represent the kinetic rates associated to a reaction. The delay chain τ is modelled with five intermediate steps. The turquoise rate is cell-type specific according to ℓ₁, purple rates are cell-type specific according to some ℓ_q and Adaptive Lasso regularizations. Lower panel: Scan over deformations for the JAK2/STAT5 signalling pathway with CFU-E and H838 cells. Parsimonious Model parameters related to the CISH feedback loop are depicted only. Dot colours represent the final unpenalized estimates. The numbers in the upper row indicate the total number of log-fold-changes not estimated to zero, also including those that are not depicted here. Squares denote the results obtained by the original ℓ₁ penalty. Circles indicate the extended methods. Two possible parsimonious models were found when scanning the deformation strengths: either CISHRNA basal and delay rates were cell-type specific or the corresponding turn rate