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Fig. 1 | BMC Bioinformatics

Fig. 1

From: RESCUE: imputing dropout events in single-cell RNA-sequencing data

Fig. 1

A motivation of the RESCUE imputation pipeline illustrated with a hypothetical example of simulated data. a Heatmap of a log-transformed normalized expression matrix with cell type clustering affected by dropout. b t-SNE visualizations of cell clusters determined with the principle components of many subsamples of informative genes, and a histogram showing the bootstrap distribution of the within-cluster non-zero gene expression means for one missing expression value in the data set. c Heatmap of the expression data after imputing zero values with a summary statistic of the bootstrap distributions

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