Fig. 1From: RESCUE: imputing dropout events in single-cell RNA-sequencing dataA motivation of the RESCUE imputation pipeline illustrated with a hypothetical example of simulated data. a Heatmap of a log-transformed normalized expression matrix with cell type clustering affected by dropout. b t-SNE visualizations of cell clusters determined with the principle components of many subsamples of informative genes, and a histogram showing the bootstrap distribution of the within-cluster non-zero gene expression means for one missing expression value in the data set. c Heatmap of the expression data after imputing zero values with a summary statistic of the bootstrap distributionsBack to article page