Fig. 3

Network generation pipeline. Representative network drawn by circlize, showing data for sample1 and interactions generated by STRING. a. Binary network containing all the identified proteins arranged in alphabetical order on the external ring of the circular plot. Thin black curves show the possible interactions generated by STRING. b. Binary network containing only the proteins with interactions. The isolated proteins (i.e. without any connection) were eliminated. Thin black curves show the possible interactions generated by STRING. c. Weighted network containing the interacting proteins. Orange lines represent interactions, the higher the intensity of the color and thickness of the line the higher the interaction strength. d. Weighted network with functional feature. A randomly selected GO function (GO:0044765) is used to illustrate the functional network. Red proteins are part of the functional sub-network, while black proteins are not, being considered as non-functional proteins. The weighted interactions are color-coded according to the protein-pair classification: functional – functional interactions are orange, non-functional – non-functional interactions are gray, and functional – non-functional interactions are green. The interaction strength is represented by the intensity of the color and thickness of the line: the higher the intensity of the color and the thickness of the line, the higher the interaction strength