Fig. 3

The NPA and the BIF. a Heatmap of the NPA scores. A network is considered perturbed if, in addition to the significance of the NPA score with respect to the experimental variation, the two companion statistics (O and K), derived to inform on the specificity of the NPA score with respect to the biology described in the network, are significant. *O and K statistic p-values below 0.05 and NPA significant with respect to the experimental variation. b BIF scores. The percentages give the relative biological impact, which is derived from the cumulated network perturbations caused by the treatment relative to the reference (the treatment showing the highest perturbation; here 3R4F as REF). Only the significant network perturbations are summarized further into this single number; hence, any component entering the score is significant by definition. The contribution to the score for each network family is indicated by a pie chart underneath each bar. For each treatment comparison, the δ value (− 1 to 1) indicates how similar the underlying network perturbations are with respect to the reference. A value of 1 indicates that all the networks are perturbed by the same mechanisms