Fig. 7

NPA of the ECM degradation network model scored with E-MTAB-2756 transcriptomic data. The bar graph on the left (panel a) represents the perturbation amplitude of the network model as a whole shown with the CIs accounting for experimental variation. The red star indicates that the score is statistically different from 0. In addition, companion statistics derived to inform on the specificity of the score with respect to the network structure are shown as *O and K*, respectively, if their p-values are below the significance level of 0.05, and by .O and K. when the corresponding p-values are between 0.05 and 0.1. Symbol legend: *: O and K statistic p-values below 0.05 (in color), .O and K. p-values between 0.05 and 0.1(in grey). The network presentation on the right (panel b) shows an example of connected leading nodes common to all contrasts. The backbone NPA values with directionalities of inferred regulation are shown as bar graphs for each node. The green asterisk indicates that the node is a leading node. Highlighted nodes are the molecules discussed in the main text. The vocabulary for the BEL is provided in http://www.openbel.org/