Fig. 5
From: A multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex
Optimization results on the control dataset. Coefficients and outputs of the model for the three parameter sets in Table 4, superimposed on experimental values represented by their mean and global range (in black). Green (#1) and blue (#2) lines correspond to a fit with neurons and IPs, red lines (#3) correspond to the fit including IPPs. Green lines correspond to the fit with γ(t) kept constant. Panel a displays the division rate γ(t). Panel b displays the input flux of AP cells FAP(t), the + signs show the location of the inflexion times t− and t+. Panel c displays the cumulative number of AP cells \(\int _{0}^{t}F_{AP}(\tau)d\tau \). Panel d displays \(\overline {IP}(t)\) computed by the model (7). Panel e displays \(\overline {IPP}(t)\) computed by the model (6). Panel f displays N(t) computed by the model (8). The value of the ratio \(r^{N}_{AP}\) for the three simulations is 3. (scenario 1 in green), 3.37 (scenario 2 in blue) and 2.73 (scenario 3 in red)