From: VarSight: prioritizing clinically reported variants with binary classification algorithms
Feature label | RF(sklearn) | BRF(imblearn) |
---|---|---|
HPO-cosine | 0.2895 | 0.2471 |
PyxisMap | 0.2207 | 0.2079 |
CADD Scaled | 0.1031 | 0.1007 |
phylop100 conservation | 0.0712 | 0.0817 |
phylop conservation | 0.0641 | 0.0810 |
phastcon100 conservation | 0.0572 | 0.0628 |
GERP rsScore | 0.0357 | 0.0416 |
HGMD assessment type_DM | 0.0373 | 0.0344 |
HGMD association confidence_High | 0.0309 | 0.0311 |
Gnomad Genome total allele count | 0.0192 | 0.0322 |
ClinVar Classification_Pathogenic | 0.0228 | 0.0200 |
ADA Boost Splice Prediction | 0.0081 | 0.0109 |
Random Forest Splice Prediction | 0.0077 | 0.0105 |
Meta Svm Prediction_D | 0.0088 | 0.0092 |
PolyPhen HV Prediction_D | 0.0075 | 0.0071 |
Effects_Premature stop | 0.0049 | 0.0057 |
SIFT Prediction_D | 0.0026 | 0.0056 |
PolyPhen HD Prediction_D | 0.0025 | 0.0049 |
Effects_Possible splicing modifier | 0.0029 | 0.0035 |
ClinVar Classification_Likely Pathogenic | 0.0034 | 0.0020 |