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Table 1 The averaged true positive rates of 4 individual tests and 5 different regularization methods when each method selected top 50 genes

From: Incorporating genetic networks into case-control association studies with high-dimensional DNA methylation data

 

ω=2

ω=4

ω=8

Method

σ=2.0

σ=2.5

σ=3.0

σ=2.0

σ=2.5

σ=3.0

σ=2.0

σ=2.5

σ=3.0

T-test

0.5595

0.4243

0.3043

0.7016

0.6263

0.5167

0.7767

0.7376

0.6689

GT

0.4662

0.3538

0.2738

0.6492

0.5176

0.4414

0.7557

0.6698

0.6002

SAM-GS

0.4452

0.3405

0.2548

0.6358

0.5186

0.4318

0.7529

0.6765

0.5964

HT

0.3519

0.2700

0.2310

0.4566

0.4118

0.3394

0.5420

0.4847

0.4351

group lasso

0.4644

0.3536

0.2842

0.6089

0.4959

0.4272

0.6697

0.6374

0.5487

Net+PLS

0.6592

0.4963

0.3969

0.8106

0.7020

0.6148

0.8733

0.7910

0.7322

Net+PC

0.6136

0.4078

0.2777

0.9141

0.8276

0.6762

0.9504

0.9145

0.8801

Net+sPC

0.7592

0.5663

0.3862

0.9066

0.8283

0.7004

0.9547

0.9310

0.8644

Net+nPC

0.8148

0.6376

0.4338

0.9276

0.8456

0.7455

0.9504

0.9103

0.8760