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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Game of neutrophils: modeling the balance between apoptosis and necrosis

Fig. 3

Exploring the payoff matrix for (left column) cNecrosis and n, (middle column) α and bApoptosis and (right column) bApoptosis and cNecrosis with varying ITMsinitial. The colors correspond to the evolutionary stable fraction of necrotic neutrophils after the game is played for varying concentrations of initial insult. A system that stabilizes at necrosis is shown dominantly red. Conversely, a system that stabilizes at apoptosis is shown in blue. Note that black area denotes solutions that are invalid. This includes p (fraction of necrotic neutrophils) that do not lie within the interval [0, 1], and those that do not obey the constraints set in Eq. (9). NT = 2500 was held constant for all simulations. On the left column, we set the value α = 1.0, bApoptosis = 0.0001, and m = 0.0015. In the middle columnn = 0.0004, m = 0.0008, cNecrosis = 0.0001 were held constant. In the right column, α = 1.0, n = 0.0004, and m = 0.0008 were fixed. The black area corresponds to invalid solutions

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