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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Game of neutrophils: modeling the balance between apoptosis and necrosis

Fig. 5

Data Parameter Space (α, bApoptosis, cNecrosis). Each point in the plot corresponds to the combination of parameters that satisfies the data. This 3-dimensional parameter data space can be better visualized via an interactive plot, which we have uploaded to the following link: https://github.com/avpresbitero/EGTN (1). The colors are chosen only to add visual depth to the plot, where purple to yellow corresponds to increasing values of α. Nature has evolved into stable percentage of necrotic and apoptotic neutrophils that correspond to a set of parameters (α, bApoptosis, cNecrosis) that exhibit direct proportionality towards each other. That is, with higher cost of necrosis, higher values for global cost of remaining ITMs is preferred. This shows that nature made necrosis to be damaging on purpose for the organism to make sure that this event only happens a few times, that is, only when necessary

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