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Fig. 9 | BMC Bioinformatics

Fig. 9

From: Game of neutrophils: modeling the balance between apoptosis and necrosis

Fig. 9

Global ITMs Scheme. Snapshots of the 50×50 lattice for 0 and 500 ITMs through iteration time (left to right). Green in the lattice corresponds to activated neutrophils, red to necrotic neutrophils, and blue to apoptotic neutrophils. Apoptosis (blue) remains dominant with less concentration of ITMs (top right). Conversely, necrosis (red) dominates with intensifying level of inflammation (bottom right). At 0 ITMs, necrotic neutrophils are better off isolated, which could be interpreted biologically as the system’s way to minimize local damage by allowing apoptotic neutrophils to settle in the space that separates them. Increasing the concentration of ITMs to 500, however reveals clustering of necrotic neutrophils together, which intensifies local tissue damage thus further aggravating the level of inflammation in the system

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