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Table 5 Epitope ensemble vaccine for HCMV

From: Computational assembly of a human Cytomegalovirus vaccine upon experimental epitope legacy

Epitope

Antigen gene

Antigen accession

BLAST hit human (%)

BLAST hit HMP (%)

PPC (%)

CD8 T cell epitope vaccine component

 QYDPVAALF

UL83

Q6SW59

NP_060360.3 (66.67)

ETS98202.1 (78.00)

66.71

 NLVPMVATV

UL83

Q6SW59

AMD82163.1 (66.67)

KWZ77571.1 (78.00)

58.98

 TTVYPPSSTAK

UL32

Q6SW99

CAC15059.1 (63.64)

OFS88048.1 (72.73)

34.47

 HERNGFTVL

UL83

Q6SW59

XP_016879611.1 (77.78)

EGG81521.1 (77.78)

24.21

 TPRVTGGGAM

UL83

Q6SW59

AGP01160.1 (70.00)

EJD64485.1 (80.00)

9.79

 QTVTSTPVQGR

UL32

Q6SW99

NP_005892.1 (63.64)

EHY57399.1 (82.00)

1.12

CD4 T cell epitope vaccine component

 SIYVYALPLKMLNIP

UL83

Q6SW59

XP_006724177.2 (46.67)

AEA20835.1 (73.33)

63.95

 KLFMHVTLGSDVEEDLTMTR

UL83

Q6SW59

EAX02867.1 (45.00)

ERJ00718.1 (45.00)

48.03

 YQEFFWDANDIYRIF

UL83

Q6SW59

EAW98902.1 (46.67)

EIJ68880.1 (60.00)

27.69

 LPLKMLNIPSINVHH

UL83

Q6SW59

EAX02055.1 (46.67)

EEU31012.1 (73.33)

21.87

 CSMENTRATKMQVIG

UL83

Q6SW59

EAW54200.1 (53.33)

EGL44246.1 (73.33)

37.99

 AGILARNLVPMVATV

UL83

Q6SW59

BAC11142.1 (46.67)

EFV13316.1 (73.33)

11.53

B cell epitope vaccine component

 AFHLLLNTYGR

UL75

Q6SW67

EAW77317.1 (63.64)

KXA44279.1 (63.64)

 

 *TYNSSLRNS

UL75

Q6SW67

AHA56189.1 (78.00)

EFE23794.1 (90.00)

 *TPEAANSVLLD

UL115

F5HCH8

NP_001017403.1 (72.73)

OFU98142.1 (72.73)

  1. We show closest blast hits to human Proteins and Human Microbiome Proteins. The B cell epitope component contains one epitope validated experimentally and 2 predicted epitopes (*). PPC of the entire CD8 and CD4 T cell component is 97.41 and 92.49%