TY - JOUR AU - Wang, Janet AU - LaFramboise, Thomas PY - 2019 DA - 2019/09/11 TI - CytoConverter: a web-based tool to convert karyotypes to genomic coordinates JO - BMC Bioinformatics SP - 467 VL - 20 IS - 1 AB - Cytogenetic nomenclature is used to describe chromosomal aberrations (or lack thereof) in a collection of cells, referred to as the cells’ karyotype. The nomenclature identifies locations on chromosomes using a system of cytogenetic bands, each with a unique name and region on a chromosome. Each band is microscopically visible after staining, and encompasses a large portion of the chromosome. More modern analyses employ genomic coordinates, which precisely specify a chromosomal location according to its distance from the end of the chromosome. Currently, there is no tool to convert cytogenetic nomenclature into genomic coordinates. Since locations of genes and other genomic features are usually specified by genomic coordinates, a conversion tool will facilitate the identification of the features that are harbored in the regions of chromosomal gain and loss that are implied by a karyotype. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-019-3062-4 DO - 10.1186/s12859-019-3062-4 ID - Wang2019 ER -