Fig. 1

An illustration of radius of gyration. a and b illustrate two TADs with the same size but different 3D structures. The stars indicate TSS. c An example of the first, second, and third line graphs of a given graph G. G is the original chain of beads, in which every two adjacent beads have an edge. L(G) is the first line graph, in which each node represents an edge in G. An edge is created in L(G) between two nodes if these two nodes represent two sequentially adjacent edges in G. In the same way, the second and third line graphs can be generated