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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Mathematical model of hypoxia and tumor signaling interplay reveals the importance of hypoxia and cell-to-cell variability in tumor growth inhibition

Fig. 3

Hypoxia induces a decrease or no change in ERK activation. a Two simulation cases showing differential sensitivity in steady-state pERK response to step reduction in O2 levels of various severity (normoxia = 100%). The time course for pERK responses to 0.1% O2 is illustrated in the insert, where x-axis is time and y-axis is the level of phosphorylated ERK. The solid bar above the line trace indicates when 0.1% O2 was applied in the simulation. b Histograms summarizing the distribution of pERK responses from all 20,000 simulation cases at various degree of hypoxia. c Decision tree analysis was used to identify which biomolecule levels are most important in determining the sensitivity of pERK to hypoxia by categorizing the simulation cases into “no change” or “decreased (within ±10% change or > 10% reduction from the normoxia level). The resultant decision tree showing that pERK/tERK ratio is the primary factor deciding if pERK is sensitive to hypoxia (0.1% O2) or not

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