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Table 1 Comparison of MIENTURNET with other web tools developed for the identification and analysis of miRNA-target interactions (MTIs)

From: MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

Tools

miTEA

GSEA/MSigDB

miEAA

miRNet

miRTargetLink

MIENTURNET

Reference

[12]

[13]

[14]

[15]

[16]

 

Last Release

February 2013

July 2018

April 2016

March 2018

April 2016

March 2019

Input list

      

Gene identifiers

Gene symbol, RefSeq, Uniprot, Unigene, Ensembl

Gene symbol, Entrez

-

Gene symbol, Ensembl, Entrez

Gene symbol

Gene symbol

miRNA identifiers

-

-

ID

ID, Accession

ID

ID

Others

-

-

-

-

-

Queries

      

Multiple item

Organisms

      

Species

Human, Mouse, Rat, Zebrafish, Fruit fly

Human

Human

Human, Mouse, Rat, Cattle, Chicken, Zebrafish, Fruit fly, Worm, Helminth

Human

Human, Mouse, Rat, Zebrafish, Fruit fly, Worm

Species #

5

1

1

9

1

6

Reference database

      

Predicted target genes

TargetScan, MicroCosm, EIMMo

MSigDB

-

miRanda

miRanda

TargetScan

Experimental target genes

-

-

miRTarBase

TarBase, miRTarBase, miRecords

miRTarBase, in-house data

miRTarBase

Others

-

-

-

-

Statistical analysis

      

Differential expression

-

-

-

-

-

Functional enrichment

-

miRNA-target enrichment

-

-

MTI network

      

Visualization

-

-

-

Customization

-

-

-

Filtering

-

-

-

MTI network analysis

      

Degree

-

-

-

-

Betweenness

-

-

-

-

Closeness

-

-

-

-

-

Average shortest path

-

-

-

-

-

Eccentricity

-

-

-

-

-

Clustering coefficient

-

-

-

-

-

Fit power low

-

-

-

-

-

  1. *miRNA identifiers from miRBase database [28]
  2. **species common name (scientific name): Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Cattle (Bos taurus), Chicken (Gallus gallus), Zebrafish (Danio rerio), Fruit fly (Drosophila melanogaster), Worm (Caenorhabditis elegans), Helminth (Schistosoma mansoni)
  3. ***only for Cattle, Chicken, Helminth