Fig. 3

AUC comparison from q = 0 to 10 for integrated networks: PPI^(0~q). The experiment was repeated 55 times, and the average AUC value with the standard deviation is presented as a circle with an error bar. PPI⁽⁰⁾, PPI⁽¹⁾, PPI⁽²⁾, and PPI⁽³⁾ are individual disease networks constructed as described in Methods section. PPI^(0~q) s are integrated networks from Eq. (6). PPI⁽⁰⁾ corresponds to the existing disease network suggested by Goh et al. [21]. A randomized network is added to our experiment to obtain a reference performance. The best performance was achieved by PPI^(0~3), and p-values of the pairwise t-tests are shown in the bottom of the plot