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Table 1 Statistics for evaluating disease-related metabolite network

From: Prioritizing candidate diseases-related metabolites based on literature and functional similarity

Disease name Disease Ontology Test node Positive group Version 2017 Version 2018
L-2-hydroxyglutaric aciduria DOID:0050574 2 4 2 4
medium chain acyl-CoA dehydrogenase deficiency DOID:0080153 1 16 15 16
short chain acyl-CoA dehydrogenase deficiency DOID:0080154 1 4 3 4
Crohn’s colitis DOID:0060192 5 8 3 16
cerebrotendinous xanthomatosis DOID:4810 5 7 2 9
maple syrup urine disease DOID:9269 6 23 17 24
abetalipoproteinemia DOID:1386 3 4 1 4
celiac disease DOID:10608 11 22 11 82
methylmalonic acidemia DOID:14749 1 2 1 2
irritable bowel syndrome DOID:9778 5 7 2 15
Fanconi syndrome DOID:1062 1 2 1 5
citrullinemia DOID:9273 6 8 2 8
inflammatory bowel disease 1 DOID:0110892 5 8 3 16
isovaleric acidemia DOID:14753 2 11 9 12
type 2 diabetes mellitus DOID:9352 1 27 27 27
aromatic L-amino acid decarboxylase deficiency DOID:0090123 2 9 7 12
cholesterol ester storage disease DOID:14502 1 2 1 2
congenital adrenal hyperplasia DOID:0050811 15 18 3 28
Crohn’s disease DOID:8778 5 8 3 16