Fig. 1From: A comparative study of topology-based pathway enrichment analysis methodsSchematics of the simulation design. In each study, real expression data is used to carry out the simulations. From left to right, the original expression data is first standardized such that each gene/metabolite has mean zero and unit variance. Varying mean signals are then added to genes/metabolites in the selected pathways in each of the simulation replicates. The top bar indicates the sample labels, which are either the original case/control status or a random permutation of the original case/control statusBack to article page