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Table 1 Effects of asynchronous I/O settings on walltime (hours) in GATK4

From: Recommendations for performance optimizations when using GATK3.8 and GATK4

 Async I/O activated?
Tool Namenoallonly for samtools I/O
BaseRecalibrator4.072.952.88
ApplyBQSR2.382.072.08
HaplotypeCaller17.2517.3117.08
  1. Sample: NA12878 WGS.