Skip to main content

Table 1 The Δ symbols and lower-cases represent deletion mutations, and OX represents over-expression modifications

From: Estimating network changes from lifespan measurements using a parsimonious gene network model of cellular aging

StrainsAverage RLSNetwork ModelGomperz ModelAIC Comparison
  Rt0nGompertz RGompertz GWeibull AICGompertz AICNetwork AIC
BY474226.6±0.5660.0047±8e−0456.2±10.17.9±0.8250.0066±0.000880.09±0.0061832.25±24.311878.29±23.161863.53±24.45
sir2Δ13.96±0.3370.0028±5e−0416.6±1.98±0.30.0035±0.00120.29±0.031483.1±15.47493.59±15.53494.34±12.18
SIR2OX34.72±1.4240.0033±7e−0465.2±7.57.8±0.5140.0038±0.001030.08±0.009457.75±8.83472.71±9.01471.46±8.46
fob1Δ37.72±1.1190.0032±6e−0471.4±5.77.6±0.4680.0035±0.000680.07±0.0061121.55±13.381133.84±13.551134.36±12.42
hxk2Δ36.77±1.5960.0057±0.001101.3±12.97.5±0.6290.0067±0.001090.05±0.0031006.87±13.511017.62±91016.83±10.47
fob1Δhxk2Δ48.46±1.5650.0051±0.0013118.1±8.36.5±0.6710.0041±0.000630.04±0.0031430.63±12.851427.9±11.461435.6±13.08
  1. Replicative lifespans of each strain were resampled 100 times using the bootstrap with replacement method. Each resampled lifespan data set was fitted with the binomial network aging model using the maximal likelihood method. The maximal likelihood estimations from fitting to 100 bootstraps were averaged