Table 2 Accuracy of the proposed Metabolic Disassembler workflow for each metabolic map
From: Metabolic disassembler for understanding and predicting the biosynthetic units of natural products
Map number | Name of the pathway map | Correctness for the first candidate | Correctness for the other candidates | Incorrect | Number of molecules | Accuracy |
|---|---|---|---|---|---|---|
00231 | Puromycin biosynthesis | 10 | 0 | 0 | 10 | 1.000 |
00232 | Caffeine metabolism | 14 | 0 | 0 | 14 | 1.000 |
00254 | Aflatoxin biosynthesis | 17 | 0 | 4 | 21 | 0.810 |
00261 | Monobactam biosynthesis | 18 | 6 | 0 | 24 | 1.000 |
00311 | Penicillin and cephalosporin biosynthesis | 12 | 0 | 0 | 12 | 1.000 |
00331 | Clavulanic acid biosynthesis | 6 | 2 | 0 | 8 | 1.000 |
00332 | Carbapenem biosynthesis | 22 | 0 | 1 | 23 | 0.957 |
00333 | Prodigiosin biosynthesis | 1 | 0 | 10 | 11 | 0.091 |
00401 | Novobiocin biosynthesis | 17 | 0 | 1 | 18 | 0.944 |
00402 | Benzoxazinoid biosynthesis | 6 | 0 | 0 | 6 | 1.000 |
00403 | Indole diterpene alkaloid biosynthesis | 30 | 0 | 0 | 30 | 1.000 |
00404 | Staurosporine biosynthesis | 32 | 0 | 0 | 32 | 1.000 |
00405 | Phenazine biosynthesis | 17 | 5 | 3 | 25 | 0.880 |
00521 | Streptomycin biosynthesis | 15 | 0 | 0 | 15 | 1.000 |
00524 | Neomycin, kanamycin and gentamicin biosynthesis | 67 | 0 | 2 | 69 | 0.971 |
00525 | Acarbose and validamycin biosynthesis | 29 | 0 | 0 | 29 | 1.000 |
00901 | Indole alkaloid biosynthesis | 54 | 1 | 1 | 56 | 0.982 |
00940 | Phenylpropanoid biosynthesis | 51 | 0 | 4 | 55 | 0.927 |
00941 | Flavonoid biosynthesis | 63 | 0 | 0 | 63 | 1.000 |
00942 | Anthocyanin biosynthesis | 63 | 0 | 0 | 63 | 1.000 |
00943 | Isoflavonoid biosynthesis | 55 | 2 | 2 | 59 | 0.966 |
00944 | Flavone and flavonol biosynthesis | 49 | 0 | 0 | 49 | 1.000 |
00945 | Stilbenoid, diarylheptanoid and gingerol biosynthesis | 21 | 2 | 0 | 23 | 1.000 |
00950 | Isoquinoline alkaloid biosynthesis | 98 | 0 | 1 | 99 | 0.990 |
00960 | Tropane, piperidine and pyridine alkaloid biosynthesis | 44 | 3 | 11 | 58 | 0.810 |
00965 | Betalain biosynthesis | 20 | 0 | 0 | 20 | 1.000 |
00966 | Glucosinolate biosynthesis | 48 | 5 | 0 | 53 | 1.000 |
01058 | Acridone alkaloid biosynthesis | 14 | 1 | 0 | 15 | 1.000 |
| Â | Total (without redundancy) | 876 | 27 | 40 | 943 | 0.958 |