Fig. 2

rGNN of InterPro family IPR004651 characterizing the histidine biosynthesis protein HisF. The circles represent three rep_nodes 40; their diameter corresponds to the number of corresponding sequences. The hexagons represent pf_nodes (i. e., Pfam families) that are labeled with their Pfam-IDs; the size of the hexagons corresponds to the value of f(pf_node). These pf_nodes indicate the most abundant protein functions encoded in the ± 10 genomic neighborhood of the HisF sequences. PF00117 (glutamine amidotransferase I, HisH) was correctly identified as interaction partner of HisF, because it had the largest value \( {f}_{\mathrm{max}}^{\ast}\left( pf\_ node\right) \), which was 43.6%. To reduce complexity, all nodes representing ≤ 3 sequences were eliminated for this illustration