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Table 1 The module-inferred functional binding target gene sets have equal or better biological significance than pure knockout-inferred direct regulatory targets

From: Transcription factor regulatory modules provide the molecular mechanisms for functional redundancy observed among transcription factors in yeast

Biological Aspects Results
OntologyBiological128 (70.3%) TFs showed equal or better log enrichment scores
EnrichmentProcessin module-inferred functional binding target genes while only
  54 (29.7%) TFs showed higher log enrichment scores in the
  direct regulatory data.
 Molecular109 (59.9%) TFs showed equal or better log enrichment scores
 Functionin module-inferred functional binding target genes while only
  73 (40.1%) TFs showed higher log enrichment scores in the
  direct regulatory data.
 Cellular150 (82.4%) TFs showed equal or better log enrichment scores
 Componentin module-inferred functional binding target genes while only
  34 (18.7%) TFs showed higher log enrichment scores in the
  direct regulatory data.
Protein Interaction 68 (37.4%) of the module-inferred functional binding gene
Prevalence sets reveled prevalence of protein interaction while only
  13 (7.1%) direct regulatory gene sets did.
Expression Module-inferred functional binding genes had higher
Coherence expression coherence in 32 different conditions while in no
  condition the direct regulatory data got higher expression
  coherence.