Fig. 1

Genic location and editing level of glioma editome. a Genic location of 10,642 editing sites using ANNOVAR (RefSeq gene annotation). Sites are located in one of the following ANNOVAR-defined categories: UTR3 (overlaps a 3′ untranslated region), intergenic (in intergenic region), intronic (overlaps an intron), downstream (overlaps 1-kb region downstream of transcription end site), ncRNA (overlaps a transcript without coding annotation in the gene definition), exonic (overlaps a coding), upstream (overlaps 1-kb region upstream of transcription start site), and UTR5 (overlaps a 5′ untranslated region). b Total editing level of three glioma subtypes. IDH wt: samples with wildtype isocitrate dehydrogenase (IDH); IDH mut-codel: samples with both IDH mutation and chromosome 1p/19q codeletion; IDH mut-non-codel: samples with only IDH mutation (no 1p/19q codeletion). c Total editing level of glioma subtypes considering tumor grade. G2/G3/G4: grade II, III and IV. Asterisk represents statistical difference between subtypes (Kolmogorov-Smirnov test, p < 0.0001)