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Fig. 3 | BMC Bioinformatics

Fig. 3

From: RNA editing-based classification of diffuse gliomas: predicting isocitrate dehydrogenase mutation and chromosome 1p/19q codeletion

Fig. 3

Pan-glioma RNA editing signatures. a Heatmap of RNA editing level of the 132 sites repeated selected in the IDH mutation classifiers (random forest). Columns represent z-score of RNA editing level of 132 sites sorted by hierarchical clustering. Rows represent 638 TCGA glioma samples sorted by hierarchical clustering. IDH mutation status (red: mutant; blue: wildtype) and grade information (G2/G3/G4: grade II, III and IV) of each sample is labeled. b Heatmap of z-score of RNA editing level of the 124 sites repeated selected in the 1p/19q codeletion classifiers (random forest). Columns represent RNA editing level of 124 sites sorted by hierarchical clustering. Rows represent 413 TCGA glioma samples (carrying IDH mutation) sorted by hierarchical clustering. 1p/19q codeletion status (red: codeletion / blue: non-codeletion) of each sample is labeled

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