Fig. 11

Distribution of maximal values of activity modes within connected components in comparison to randomised data. (Left) Distribution of maximal values of activity modes a_i within connected components (blue line) in comparison with value distribution when edges (with the same type labels) are assigned to components randomly (orange line). For both data sets the values are sorted in decreasing order with each point on x axis corresponding to one component limited to a single cell type. The activity values shown on y axis due to normalisation range between 0 and 1. The chart shows that edges within connected components tend to be significantly more associated to component-specific activity modes than it will be expected from random edge assignments to components. The p-value assigned by Wilcoxon test to statistical significance of this effect was 2.2×10⁻¹⁶ (i.e. ’almost zero’). (Right) Box plots showing distributions of real and randomised data. The data are shown for chromosome 6, but the same very low p-value was obtained for all the chromosomes