TY - JOUR AU - Cui, Hongfei AU - Hu, Hailin AU - Zeng, Jianyang AU - Chen, Ting PY - 2019 DA - 2019/12/20 TI - DeepShape: estimating isoform-level ribosome abundance and distribution with Ribo-seq data JO - BMC Bioinformatics SP - 678 VL - 20 IS - 24 AB - Ribosome profiling brings insight to the process of translation. A basic step in profile construction at transcript level is to map Ribo-seq data to transcripts, and then assign a huge number of multiple-mapped reads to similar isoforms. Existing methods either discard the multiple mapped-reads, or allocate them randomly, or assign them proportionally according to transcript abundance estimated from RNA-seq data. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-019-3244-0 DO - 10.1186/s12859-019-3244-0 ID - Cui2019 ER -