Fig. 2

Merge of ALS protein network (cyan colored nodes) and retrovirus protein network (rose colored nodes) with overlap nodes in both networks (blue colored nodes). The size of nodes represents the degree and between-ness of nodes. The protein network topology and statistical analysis by Cytoscape network analyzers showed the importance of the nodes in each network based on a series of topological parameters, including the node centrality measure and node degree. The positions of nodes within this joined protein network are determined by topological parameters derived from Cytoscape’s algorithm for merging networks. The joined network is visualized based on the node degree (represented by node size) and edge betweenness parameters (represented by location and sizes of edges). Values of edge betweenness were mapped with the edge size: high values of this parameter correspond to a large edge size