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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Association between ALS and retroviruses: evidence from bioinformatics analysis

Fig. 3

a A MCODE Cluster within shared subnetwork of ALS protein network and retrovirus protein network. The nodes (proteins) that are yellow are retained in the MCODE Cluster after analysis, based on their parameters, including Connectivity, Degree and Centrality. The table outlines the degree, neighborhood connectivity and closeness centrality values of the MCODE Cluster Nodes. The neighborhood connectivity of a node is defined as the average connectivity of all neighbors. The closeness centrality is a number between 0 and 1 and measures how fast information spreads from a given node to other nodes in the network. The rose colored nodes are within shared subnetwork but excluded from the MCOD Cluster. b. Clue-Go analysis identifies KEGG pathways and biological processes linked to the essential proteins in the Core Cluster. c. IPA pathway analysis identifies canonical pathways linked to the Core Cluster proteins

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