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Fig. 6 | BMC Bioinformatics

Fig. 6

From: HKPocket: human kinase pocket database for drug design

Fig. 6

The pocket information of AGC_P_0. The information of AGC_P_0 pocket cluster contains three parts: Sequence WebLogo, Pocket Visualization, and Pocket Information. (1) A WebLogo plot was generated to show the sequence conservation of the pocket. The overall height of the residues in WebLogo indicates the frequency and conservation at the corresponding position. For AGC_P_0 pocket, the G3, V8, A9, K11, G28, R32, D33, K35, N36, and D40 residues are highly conserved. (2) Users can scale and rotate the AGC_P_0 pocket structure. HKPocket provides four representations: “spacefill”, “wire”, “ball&stick”, and “cartoon”. The key residues can be highlighted in different colors. Users can also generate and save the picture. (3) A pocket information table contains the structural shape (volume, surface, depth, etc.), sequence (negative amino acid ratio, polar amino acid ratio, etc.), atom (the number of metals, carbons, etc.), hydrophilic-hydrophobic, critical interactions and druggability information of cluster pockets

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