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Table 1 Main characteristic of included studies

From: BIN1 rs744373 variant shows different association with Alzheimer’s disease in Caucasian and Asian populations

StudyPopulation/CityEthnicityCaseControlMAF (C)ORGenotype Platform
NFemale (%)Age+ (mean ± SD)NFemale (%)Age+ (mean ± SD)
Miyashita 2013 [32]JapaneseEast Asian10087273.0 ± 4.3101657%77.0 ± 5.90.331.11Affymetrix GeneChip
Miyashita 2013 [32]KoreansEast Asian3397273.7 ± 9.5112949%71.0 ± 4.90.360.97TaqMan
Xiao 2015 [33]ChineseEast Asian45950.371.2 ± 9.675152.972.7 ± 5.90.371.07iPLEX
Huang 2016 [34]TibetansEast Asian39NANA56NANA0.321.04PCR
Jiao 2015 [35]ChineseEast Asian22956.975.2 ± 5.031853.271.6 ± 2.50.360.70PCR-RFLP
Liao 2014 [35]ChineseEast Asian53546.379.6 ± 7.91801NANA0.371.04TaqMan
Tan 2013 [25]ChineseEast Asian61252.580.9 ± 7.561246.974.9 ± 6.30.340.66TaqMan
Ohara 2012 [29]JapaneseEast Asian82577.183.2 ± 6.529335660.2 ± 11.50.321.44PCR-RFLP
Li 2015 [26]ChineseEast Asian42054.367.7 ± 9.844159.268.5 ± 9.40.382.08PCR-RFLP
Wang 2014 [27]Chinese (Southwest)East Asian333NANA334NANA0.361.24PCR-RFLP
Wang 2014 [27]Chinese (East)East Asian415NANA426NANA0.351.08PCR-RFLP
Carrasquillo 2011 [22]AutopsyCaucasian29667.587.3 ± 4.89552.585.9 ± 4.30.300.95TaqMan
Carrasquillo 2011 [22]JacksonvilleCaucasian48762.280.1 ± 6.594956.381.6 ± 7.60.291.08TaqMan
Carrasquillo 2011 [22]NorwayCaucasian34070.180.2 ± 7.355059.775.4 ± 7.30.311.00TaqMan
Carrasquillo 2011 [22]RochesterCaucasian3106285.7 ± 4.5161954.680.3 ± 5.20.270.79TaqMan
Carrasquillo 2011 [22]southamptonCaucasian3566.781.2 ± 6.512848.576.3 ± 6.30.320.94TaqMan
Carrasquillo 2011 [22]BristolCaucasian1355876.9 ± 7.3325575.8 ± 6.40.271.12TaqMan
Carrasquillo 2011 [22]LeedsCaucasian11350.475.1 ± 6.427249.376.9 ± 6.20.290.94TaqMan
Carrasquillo 2011 [22]Man/NottsCaucasian17357.975.8 ± 9.48438.273.1 ± 8.30.350.99TaqMan
Carrasquillo 2011 [22]NCRADCaucasian69064.775.2 ± 6.820261.778.3 ± 8.90.301.00TaqMan
Carrasquillo 2011 [22]OxfordCaucasian984973 ± 7.220357.177.2 ± 80.310.89TaqMan
Carrasquillo 2011 [22]PolandCaucasian46866.276.7 ± 4.818077.273.0 ± 5.90.281.00TaqMan
Lambert 2011 [24]FinlandCaucasian5636871.3 ± 7.45295869.0 ± 6.40.240.90TaqMan
Lambert 2011 [24]ItalyCaucasian14606876.6 ± 8.712655572.3 ± 8.90.280.89TaqMan
Lambert 2011 [24]SpainCaucasian7265775.3 ± 9.38296276.9 ± 10.90.290.53TaqMan
Harold 2009 [5]IrelandCaucasian222765NA469753NA0.290.85Illumina platforms
Harold 2009 [5]GermanyCaucasian55564NA82451NA0.300.89Illumina platforms
Harold 2009 [5]USACaucasian55158NA92956NA0.291.00Illumina platforms
Ramos 2016 [28]BrazilianCaucasian8265.981.2 ± 7.515973.079.2 ± 7.80.340.98PCR-RFLP
Gharesouran 2014 [36]IranCaucasian16058.876.1 ± 7.816358.2875.3 ± 6.80.090.82PCR-RFLP
Hu 2011 [23]USACaucasian1034NANA1186NANA0.300.88Illumina 610Quad, HumanHap550
Carrasquillo 2014 [37]USACaucasian547661.3 ± 9.22397NANA0.270.95TaqMan
Seshadri 2010 [38]white peopleCaucasian3006NANA14,642NANA0.290.93Various Illumina chips, Affymetrix GeneChip
Seshadri 2010 [38]FranceCaucasian2032NANA5328NANA0.290.84Illumina Human 610Quad
Seshadri 2010 [38]SpainCaucasian114069.978.8 ± 7.9120952.849.9 ± 9.20.280.88PCR-RFLP
Nizamutdinov 2013 [39]MoscowCaucasian166NANA128NANA0.330.90Biochip
Moreno 2017 [40]ColombianCaucasian28076.175.5 ± 7.235773.971.0 ± 7.10.291.12PCR-RFLP
  1. N, Number of subjects; SD, Standard Deviation, MAF (C), Minor Allele (allele C of rs744373) Frequency; OR, odds ratio
  2. + Do not distinguish “Age at onset” or “age at exam (study)”