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Table 1 Main characteristic of included studies

From: BIN1 rs744373 variant shows different association with Alzheimer’s disease in Caucasian and Asian populations

Study

Population/City

Ethnicity

Case

Control

MAF (C)

OR

Genotype Platform

N

Female (%)

Age+ (mean ± SD)

N

Female (%)

Age+ (mean ± SD)

Miyashita 2013 [32]

Japanese

East Asian

1008

72

73.0 ± 4.3

1016

57%

77.0 ± 5.9

0.33

1.11

Affymetrix GeneChip

Miyashita 2013 [32]

Koreans

East Asian

339

72

73.7 ± 9.5

1129

49%

71.0 ± 4.9

0.36

0.97

TaqMan

Xiao 2015 [33]

Chinese

East Asian

459

50.3

71.2 ± 9.6

751

52.9

72.7 ± 5.9

0.37

1.07

iPLEX

Huang 2016 [34]

Tibetans

East Asian

39

NA

NA

56

NA

NA

0.32

1.04

PCR

Jiao 2015 [35]

Chinese

East Asian

229

56.9

75.2 ± 5.0

318

53.2

71.6 ± 2.5

0.36

0.70

PCR-RFLP

Liao 2014 [35]

Chinese

East Asian

535

46.3

79.6 ± 7.9

1801

NA

NA

0.37

1.04

TaqMan

Tan 2013 [25]

Chinese

East Asian

612

52.5

80.9 ± 7.5

612

46.9

74.9 ± 6.3

0.34

0.66

TaqMan

Ohara 2012 [29]

Japanese

East Asian

825

77.1

83.2 ± 6.5

2933

56

60.2 ± 11.5

0.32

1.44

PCR-RFLP

Li 2015 [26]

Chinese

East Asian

420

54.3

67.7 ± 9.8

441

59.2

68.5 ± 9.4

0.38

2.08

PCR-RFLP

Wang 2014 [27]

Chinese (Southwest)

East Asian

333

NA

NA

334

NA

NA

0.36

1.24

PCR-RFLP

Wang 2014 [27]

Chinese (East)

East Asian

415

NA

NA

426

NA

NA

0.35

1.08

PCR-RFLP

Carrasquillo 2011 [22]

Autopsy

Caucasian

296

67.5

87.3 ± 4.8

95

52.5

85.9 ± 4.3

0.30

0.95

TaqMan

Carrasquillo 2011 [22]

Jacksonville

Caucasian

487

62.2

80.1 ± 6.5

949

56.3

81.6 ± 7.6

0.29

1.08

TaqMan

Carrasquillo 2011 [22]

Norway

Caucasian

340

70.1

80.2 ± 7.3

550

59.7

75.4 ± 7.3

0.31

1.00

TaqMan

Carrasquillo 2011 [22]

Rochester

Caucasian

310

62

85.7 ± 4.5

1619

54.6

80.3 ± 5.2

0.27

0.79

TaqMan

Carrasquillo 2011 [22]

southampton

Caucasian

35

66.7

81.2 ± 6.5

128

48.5

76.3 ± 6.3

0.32

0.94

TaqMan

Carrasquillo 2011 [22]

Bristol

Caucasian

135

58

76.9 ± 7.3

32

55

75.8 ± 6.4

0.27

1.12

TaqMan

Carrasquillo 2011 [22]

Leeds

Caucasian

113

50.4

75.1 ± 6.4

272

49.3

76.9 ± 6.2

0.29

0.94

TaqMan

Carrasquillo 2011 [22]

Man/Notts

Caucasian

173

57.9

75.8 ± 9.4

84

38.2

73.1 ± 8.3

0.35

0.99

TaqMan

Carrasquillo 2011 [22]

NCRAD

Caucasian

690

64.7

75.2 ± 6.8

202

61.7

78.3 ± 8.9

0.30

1.00

TaqMan

Carrasquillo 2011 [22]

Oxford

Caucasian

98

49

73 ± 7.2

203

57.1

77.2 ± 8

0.31

0.89

TaqMan

Carrasquillo 2011 [22]

Poland

Caucasian

468

66.2

76.7 ± 4.8

180

77.2

73.0 ± 5.9

0.28

1.00

TaqMan

Lambert 2011 [24]

Finland

Caucasian

563

68

71.3 ± 7.4

529

58

69.0 ± 6.4

0.24

0.90

TaqMan

Lambert 2011 [24]

Italy

Caucasian

1460

68

76.6 ± 8.7

1265

55

72.3 ± 8.9

0.28

0.89

TaqMan

Lambert 2011 [24]

Spain

Caucasian

726

57

75.3 ± 9.3

829

62

76.9 ± 10.9

0.29

0.53

TaqMan

Harold 2009 [5]

Ireland

Caucasian

2227

65

NA

4697

53

NA

0.29

0.85

Illumina platforms

Harold 2009 [5]

Germany

Caucasian

555

64

NA

824

51

NA

0.30

0.89

Illumina platforms

Harold 2009 [5]

USA

Caucasian

551

58

NA

929

56

NA

0.29

1.00

Illumina platforms

Ramos 2016 [28]

Brazilian

Caucasian

82

65.9

81.2 ± 7.5

159

73.0

79.2 ± 7.8

0.34

0.98

PCR-RFLP

Gharesouran 2014 [36]

Iran

Caucasian

160

58.8

76.1 ± 7.8

163

58.28

75.3 ± 6.8

0.09

0.82

PCR-RFLP

Hu 2011 [23]

USA

Caucasian

1034

NA

NA

1186

NA

NA

0.30

0.88

Illumina 610Quad, HumanHap550

Carrasquillo 2014 [37]

USA

Caucasian

54

76

61.3 ± 9.2

2397

NA

NA

0.27

0.95

TaqMan

Seshadri 2010 [38]

white people

Caucasian

3006

NA

NA

14,642

NA

NA

0.29

0.93

Various Illumina chips, Affymetrix GeneChip

Seshadri 2010 [38]

France

Caucasian

2032

NA

NA

5328

NA

NA

0.29

0.84

Illumina Human 610Quad

Seshadri 2010 [38]

Spain

Caucasian

1140

69.9

78.8 ± 7.9

1209

52.8

49.9 ± 9.2

0.28

0.88

PCR-RFLP

Nizamutdinov 2013 [39]

Moscow

Caucasian

166

NA

NA

128

NA

NA

0.33

0.90

Biochip

Moreno 2017 [40]

Colombian

Caucasian

280

76.1

75.5 ± 7.2

357

73.9

71.0 ± 7.1

0.29

1.12

PCR-RFLP

  1. N, Number of subjects; SD, Standard Deviation, MAF (C), Minor Allele (allele C of rs744373) Frequency; OR, odds ratio
  2. + Do not distinguish “Age at onset” or “age at exam (study)”