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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures

Fig. 1

Workflow of repertoire fingerprinting by principal component analysis. To perform repertoire fingerprinting we first sequenced antibody genes of human donors and tabulated the IGHV-IGHJ gene pair usages. We then processed the data by subsampling to uniform depth over 10 replicates per donor and normalized counts by Z score transformation. We used PCA to project the input features onto 2 dimensions and analyze gene pairs that contribute to differences between repertoires

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BMC Bioinformatics

ISSN: 1471-2105

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