Table 3 Over representation analysis results of the msPLS analysis on Marfan data
From: Multiset sparse partial least squares path modeling for high dimensional omics data analysis
| Pathway name | p-value | Associated with Marfan disease through pathway |
|---|---|---|
| Influenza Virus Induced Apoptosis | 3.41 ×10−5 | Not known* |
| Non-integrin membrane-ECM interactions | 2.92 ×10−4 | Collagene formation [31] |
| Anchoring fibril formation | 4.73 ×10−4 | Collagene formation [31] |
| ECM proteoglycans | 6.19 ×10−4 | Extracellular matrix organization [31] |
| Integrin cell surface interactions | 7.90 ×10−4 | Extracellular matrix organization [31] |
| Transcriptional activation of mitochondrial biogenesis | 8.17 ×10−4 | Possibly through reduced mitochondrial respiration [32] |
| Crosslinking of collagen fibrils | 1.20 ×10−3 | Collagene formation [31] |
| Laminin interactions | 1.98 ×10−3 | Extracellular matrix organization [31] |
| Mitochondrial biogenesis | 2.40 ×10−3 | Possibly through reduced mitochondrial respiration [32] |
| NCAM1 interactions | 3.92 ×10−3 | NCAM signaling for neurite out-growth [33] |
| Collagen chain trimerization | 3.92 ×10−3 | Collagene biosynthesis and modifying enzymes [31] |
| TGFBR2 MSI Frameshift Mutants in Cancer | 4.20 ×10−3 | Signaling by TGF-beta receptor complex [31] |
| Extracellular matrix organization | 4.82 ×10−3 | Extracellular matrix organization [31] |
| Host Interactions with Influenza Factors | 5.02 ×10−3 | Not known* |
| Organelle biogenesis and maintenance | 5.14 ×10−3 | Possibly through reduced mitochondrial respiration [32] |
| Transfer of LPS from LBP carrier to CD14 | 6.30 ×10−3 | Possibly through toll-like receptor-4 signaling [34] |
| Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus | 6.30 ×10−3 | Not known* |
| Loss of Function of TGFBR2 in Cancer | 8.39 ×10−3 | Signaling by TGF-beta receptor complex [31] |
| TGFBR1 LBD Mutants in Cancer | 8.39 ×10−3 | Signaling by TGF-beta receptor complex [31] |
| TGFBR2 Kinase Domain Mutants in Cancer | 8.39 ×10−3 | Signaling by TGF-beta receptor complex [31] |
| Assembly of collagen fibrils and other multimeric structures | 8.81 ×10−3 | Collagene formation [31] |
| Collagen degradation | 9.32 ×10−3 | Degradation of the extracellular matrix [31] |
| NCAM signaling for neurite out-growth | 9.58 ×10−3 | NCAM signaling for neurite out-growth [33] |
| Interleukin-4 and Interleukin-13 signaling | 9.78 ×10−3 | Vascular inflammation through interleukins [35, 36] |
| Collagen biosynthesis and modifying enzymes | 1.12 ×10−2 | Collagene formation [31] |
| TGFBR1 KD Mutants in Cancer | 1.26 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| Loss of Function of TGFBR1 in Cancer | 1.46 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.46 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| Assembly of Viral Components at the Budding Site | 1.46 ×10−2 | Not known* |
| Loss of Function of SMAD2/3 in Cancer | 1.67 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| RUNX3 regulates CDKN1A transcription | 1.67 ×10−2 | Signaling by TGF-beta receptor complex [37] |
| Signaling by TGF-beta Receptor Complex in Cancer | 1.88 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| Collagen formation | 2.02 ×10−2 | Extracellular matrix organization [31] |
| Transcriptional regulation of white adipocyte differentiation | 2.17 ×10−2 | Possibly by depleted or abnormal adipose tissue [38] |
| Aromatic amines can be N-hydroxylated | ||
| or N-dealkylated by CYP1A2 | 2.29 ×10−2 | Not known |
| Formation of annular gap junctions | 2.29 ×10−2 | Endothelial dysfunction [39] |
| Gap junction degradation | 2.50 ×10−2 | Endothelial dysfunction [39] |
| Proton-coupled monocarboxylate transport | 2.50 ×10−2 | Not known |
| RUNX3 regulates p14-ARF | 3.31 ×10−2 | Signaling by TGF-beta receptor complex [37] |
| Fusion of the Influenza Virion to the Host Cell Endosome | 3.52 ×10−2 | Not known* |
| Packaging of Eight RNA Segments | 3.52 ×10−2 | Not known* |
| Fusion and Uncoating of the Influenza Virion | 3.72 ×10−2 | Not known* |
| Uncoating of the Influenza Virion | 3.72 ×10−2 | Not known* |
| Budding | 3.72 ×10−2 | Not known* |
| Release | 3.72 ×10−2 | Not known* |
| Biosynthesis of protectins | 3.72 ×10−2 | Possibly by proresolving lipid mediators [40] |
| Degradation of the extracellular matrix | 3.87 ×10−2 | Extracellular matrix organization [31] |
| RHO GTPases Activate Formins | 3.92 ×10−2 | Extracellular matrix organization [41] |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 3.92 ×10−2 | Signaling by TGF-beta receptor complex [31] |
| Cell-extracellular matrix interactions | 3.92 ×10−2 | Extracellular matrix organization [31] |
| Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | 4.13 ×10−2 | Arachidonic acid metabolism [42] |
| Entry of Influenza Virion into Host Cell via Endocytosis | 4.13 ×10−2 | Not known* |
| Virus Assembly and Release | 4.13 ×10−2 | Not known* |
| Biosynthesis of maresin-like SPMs | 4.33 ×10−2 | Possibly by proresolving lipid mediators [40] |
| Biosynthesis of specialized proresolving mediators (SPMs) | 4.41 ×10−2 | Possibly by proresolving lipid mediators [40] |
| Cytokine Signaling in Immune system | 4.49 ×10−2 | Cytokine signaling [31] |
| Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 4.73 ×10−2 | Arachidonic acid metabolism [42] |
| Arachidonic acid metabolism | 4.76 ×10−2 | Arachidonic acid metabolism [42] |