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Table 3 Over representation analysis results of the msPLS analysis on Marfan data

From: Multiset sparse partial least squares path modeling for high dimensional omics data analysis

Pathway name p-value Associated with Marfan disease through pathway
Influenza Virus Induced Apoptosis 3.41 ×10−5 Not known*
Non-integrin membrane-ECM interactions 2.92 ×10−4 Collagene formation [31]
Anchoring fibril formation 4.73 ×10−4 Collagene formation [31]
ECM proteoglycans 6.19 ×10−4 Extracellular matrix organization [31]
Integrin cell surface interactions 7.90 ×10−4 Extracellular matrix organization [31]
Transcriptional activation of mitochondrial biogenesis 8.17 ×10−4 Possibly through reduced mitochondrial respiration [32]
Crosslinking of collagen fibrils 1.20 ×10−3 Collagene formation [31]
Laminin interactions 1.98 ×10−3 Extracellular matrix organization [31]
Mitochondrial biogenesis 2.40 ×10−3 Possibly through reduced mitochondrial respiration [32]
NCAM1 interactions 3.92 ×10−3 NCAM signaling for neurite out-growth [33]
Collagen chain trimerization 3.92 ×10−3 Collagene biosynthesis and modifying enzymes [31]
TGFBR2 MSI Frameshift Mutants in Cancer 4.20 ×10−3 Signaling by TGF-beta receptor complex [31]
Extracellular matrix organization 4.82 ×10−3 Extracellular matrix organization [31]
Host Interactions with Influenza Factors 5.02 ×10−3 Not known*
Organelle biogenesis and maintenance 5.14 ×10−3 Possibly through reduced mitochondrial respiration [32]
Transfer of LPS from LBP carrier to CD14 6.30 ×10−3 Possibly through toll-like receptor-4 signaling [34]
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus 6.30 ×10−3 Not known*
Loss of Function of TGFBR2 in Cancer 8.39 ×10−3 Signaling by TGF-beta receptor complex [31]
TGFBR1 LBD Mutants in Cancer 8.39 ×10−3 Signaling by TGF-beta receptor complex [31]
TGFBR2 Kinase Domain Mutants in Cancer 8.39 ×10−3 Signaling by TGF-beta receptor complex [31]
Assembly of collagen fibrils and other multimeric structures 8.81 ×10−3 Collagene formation [31]
Collagen degradation 9.32 ×10−3 Degradation of the extracellular matrix [31]
NCAM signaling for neurite out-growth 9.58 ×10−3 NCAM signaling for neurite out-growth [33]
Interleukin-4 and Interleukin-13 signaling 9.78 ×10−3 Vascular inflammation through interleukins [35, 36]
Collagen biosynthesis and modifying enzymes 1.12 ×10−2 Collagene formation [31]
TGFBR1 KD Mutants in Cancer 1.26 ×10−2 Signaling by TGF-beta receptor complex [31]
Loss of Function of TGFBR1 in Cancer 1.46 ×10−2 Signaling by TGF-beta receptor complex [31]
SMAD2/3 Phosphorylation Motif Mutants in Cancer 1.46 ×10−2 Signaling by TGF-beta receptor complex [31]
Assembly of Viral Components at the Budding Site 1.46 ×10−2 Not known*
Loss of Function of SMAD2/3 in Cancer 1.67 ×10−2 Signaling by TGF-beta receptor complex [31]
RUNX3 regulates CDKN1A transcription 1.67 ×10−2 Signaling by TGF-beta receptor complex [37]
Signaling by TGF-beta Receptor Complex in Cancer 1.88 ×10−2 Signaling by TGF-beta receptor complex [31]
Collagen formation 2.02 ×10−2 Extracellular matrix organization [31]
Transcriptional regulation of white adipocyte differentiation 2.17 ×10−2 Possibly by depleted or abnormal adipose tissue [38]
Aromatic amines can be N-hydroxylated
or N-dealkylated by CYP1A2 2.29 ×10−2 Not known
Formation of annular gap junctions 2.29 ×10−2 Endothelial dysfunction [39]
Gap junction degradation 2.50 ×10−2 Endothelial dysfunction [39]
Proton-coupled monocarboxylate transport 2.50 ×10−2 Not known
RUNX3 regulates p14-ARF 3.31 ×10−2 Signaling by TGF-beta receptor complex [37]
Fusion of the Influenza Virion to the Host Cell Endosome 3.52 ×10−2 Not known*
Packaging of Eight RNA Segments 3.52 ×10−2 Not known*
Fusion and Uncoating of the Influenza Virion 3.72 ×10−2 Not known*
Uncoating of the Influenza Virion 3.72 ×10−2 Not known*
Budding 3.72 ×10−2 Not known*
Release 3.72 ×10−2 Not known*
Biosynthesis of protectins 3.72 ×10−2 Possibly by proresolving lipid mediators [40]
Degradation of the extracellular matrix 3.87 ×10−2 Extracellular matrix organization [31]
RHO GTPases Activate Formins 3.92 ×10−2 Extracellular matrix organization [41]
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 3.92 ×10−2 Signaling by TGF-beta receptor complex [31]
Cell-extracellular matrix interactions 3.92 ×10−2 Extracellular matrix organization [31]
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 4.13 ×10−2 Arachidonic acid metabolism [42]
Entry of Influenza Virion into Host Cell via Endocytosis 4.13 ×10−2 Not known*
Virus Assembly and Release 4.13 ×10−2 Not known*
Biosynthesis of maresin-like SPMs 4.33 ×10−2 Possibly by proresolving lipid mediators [40]
Biosynthesis of specialized proresolving mediators (SPMs) 4.41 ×10−2 Possibly by proresolving lipid mediators [40]
Cytokine Signaling in Immune system 4.49 ×10−2 Cytokine signaling [31]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 4.73 ×10−2 Arachidonic acid metabolism [42]
Arachidonic acid metabolism 4.76 ×10−2 Arachidonic acid metabolism [42]
  1. The pathway names and p-values are obtained from https://reactome.org. Not known associations marked with asterisk (*) are all biomolecular pathways associated with reactions to Influenza virus