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Table 3 Over representation analysis results of the msPLS analysis on Marfan data

From: Multiset sparse partial least squares path modeling for high dimensional omics data analysis

Pathway namep-valueAssociated with Marfan disease through pathway
Influenza Virus Induced Apoptosis3.41 ×10−5Not known*
Non-integrin membrane-ECM interactions2.92 ×10−4Collagene formation [31]
Anchoring fibril formation4.73 ×10−4Collagene formation [31]
ECM proteoglycans6.19 ×10−4Extracellular matrix organization [31]
Integrin cell surface interactions7.90 ×10−4Extracellular matrix organization [31]
Transcriptional activation of mitochondrial biogenesis8.17 ×10−4Possibly through reduced mitochondrial respiration [32]
Crosslinking of collagen fibrils1.20 ×10−3Collagene formation [31]
Laminin interactions1.98 ×10−3Extracellular matrix organization [31]
Mitochondrial biogenesis2.40 ×10−3Possibly through reduced mitochondrial respiration [32]
NCAM1 interactions3.92 ×10−3NCAM signaling for neurite out-growth [33]
Collagen chain trimerization3.92 ×10−3Collagene biosynthesis and modifying enzymes [31]
TGFBR2 MSI Frameshift Mutants in Cancer4.20 ×10−3Signaling by TGF-beta receptor complex [31]
Extracellular matrix organization4.82 ×10−3Extracellular matrix organization [31]
Host Interactions with Influenza Factors5.02 ×10−3Not known*
Organelle biogenesis and maintenance5.14 ×10−3Possibly through reduced mitochondrial respiration [32]
Transfer of LPS from LBP carrier to CD146.30 ×10−3Possibly through toll-like receptor-4 signaling [34]
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus6.30 ×10−3Not known*
Loss of Function of TGFBR2 in Cancer8.39 ×10−3Signaling by TGF-beta receptor complex [31]
TGFBR1 LBD Mutants in Cancer8.39 ×10−3Signaling by TGF-beta receptor complex [31]
TGFBR2 Kinase Domain Mutants in Cancer8.39 ×10−3Signaling by TGF-beta receptor complex [31]
Assembly of collagen fibrils and other multimeric structures8.81 ×10−3Collagene formation [31]
Collagen degradation9.32 ×10−3Degradation of the extracellular matrix [31]
NCAM signaling for neurite out-growth9.58 ×10−3NCAM signaling for neurite out-growth [33]
Interleukin-4 and Interleukin-13 signaling9.78 ×10−3Vascular inflammation through interleukins [35, 36]
Collagen biosynthesis and modifying enzymes1.12 ×10−2Collagene formation [31]
TGFBR1 KD Mutants in Cancer1.26 ×10−2Signaling by TGF-beta receptor complex [31]
Loss of Function of TGFBR1 in Cancer1.46 ×10−2Signaling by TGF-beta receptor complex [31]
SMAD2/3 Phosphorylation Motif Mutants in Cancer1.46 ×10−2Signaling by TGF-beta receptor complex [31]
Assembly of Viral Components at the Budding Site1.46 ×10−2Not known*
Loss of Function of SMAD2/3 in Cancer1.67 ×10−2Signaling by TGF-beta receptor complex [31]
RUNX3 regulates CDKN1A transcription1.67 ×10−2Signaling by TGF-beta receptor complex [37]
Signaling by TGF-beta Receptor Complex in Cancer1.88 ×10−2Signaling by TGF-beta receptor complex [31]
Collagen formation2.02 ×10−2Extracellular matrix organization [31]
Transcriptional regulation of white adipocyte differentiation2.17 ×10−2Possibly by depleted or abnormal adipose tissue [38]
Aromatic amines can be N-hydroxylated
or N-dealkylated by CYP1A22.29 ×10−2Not known
Formation of annular gap junctions2.29 ×10−2Endothelial dysfunction [39]
Gap junction degradation2.50 ×10−2Endothelial dysfunction [39]
Proton-coupled monocarboxylate transport2.50 ×10−2Not known
RUNX3 regulates p14-ARF3.31 ×10−2Signaling by TGF-beta receptor complex [37]
Fusion of the Influenza Virion to the Host Cell Endosome3.52 ×10−2Not known*
Packaging of Eight RNA Segments3.52 ×10−2Not known*
Fusion and Uncoating of the Influenza Virion3.72 ×10−2Not known*
Uncoating of the Influenza Virion3.72 ×10−2Not known*
Budding3.72 ×10−2Not known*
Release3.72 ×10−2Not known*
Biosynthesis of protectins3.72 ×10−2Possibly by proresolving lipid mediators [40]
Degradation of the extracellular matrix3.87 ×10−2Extracellular matrix organization [31]
RHO GTPases Activate Formins3.92 ×10−2Extracellular matrix organization [41]
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)3.92 ×10−2Signaling by TGF-beta receptor complex [31]
Cell-extracellular matrix interactions3.92 ×10−2Extracellular matrix organization [31]
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)4.13 ×10−2Arachidonic acid metabolism [42]
Entry of Influenza Virion into Host Cell via Endocytosis4.13 ×10−2Not known*
Virus Assembly and Release4.13 ×10−2Not known*
Biosynthesis of maresin-like SPMs4.33 ×10−2Possibly by proresolving lipid mediators [40]
Biosynthesis of specialized proresolving mediators (SPMs)4.41 ×10−2Possibly by proresolving lipid mediators [40]
Cytokine Signaling in Immune system4.49 ×10−2Cytokine signaling [31]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)4.73 ×10−2Arachidonic acid metabolism [42]
Arachidonic acid metabolism4.76 ×10−2Arachidonic acid metabolism [42]
  1. The pathway names and p-values are obtained from Not known associations marked with asterisk (*) are all biomolecular pathways associated with reactions to Influenza virus