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Table 1 LMAP_S listing of integrated software (31) and related stages

From: LMAP_S: Lightweight Multigene Alignment and Phylogeny eStimation

LMAP_S Stage

Integrated Software

References

Algorithms Implemented

Stage 2 (AE)

Clustal Omega (v.1.2.1)

[61]

Default

ClustalW (v.2.1)

[62]

Default

Dialign-tx (v.1.0.2)

[63]

(3) Dialign-tx Default; Dialign-tx -D option; Dialign-tx -T option

FSA (v.1.15.9)

[64]

(2) FSA Default; FSA with ‘nucprot’ option

GramAlign (v.3.0)

[65]

Default

Kalign (v.2.04)

[66]

Default

MACSE (v.1.0.2)

[67]

(2) MACSE Default, MACSE with pseudogene alignment

MAFFT (v.7.271)

[68]

(8) MAFFT Default, MAFFT with ‘auto’ option, MAFFT E-INS-I, MAFFT FFT-NS-1, MAFFT FFT-NS-2, MAFFT FFT-NS-I, MAFFT G-INS-I, MAFFT L-INS-I

MUSCLE (v.3.8.31)

[26]

Default

Opal (v.2.1.3)

[69]

Default

Prank (v.150803)

[27]

(6) Prank Default, Prank +F option, Prank ‘once’ option, Prank CODON, Prank CODON + F option, Prank CODON ‘once’ option.

ProbAlign (v.1.4)

[70]

Default

ProbCons (v.1.12)

[71]

Default

T-COFFEE (v.11.00.8cbe486)

[72]

(4) Default ‘PROBA_PAIR’, ‘T_COFFEE_MSA’, ‘KTUP_MSA’, ‘PLIB_MSA’

Stage 3 (AOD)

OD-Seq (v.1.0)

[73]

Default

EvalMSA (v.1.0)

[74]

Default

Stage 4 (ARC)

Gblocks (v.0.91b)

[29, 75]

(2) Default DNA, Default CODON

MaxAlign (v.1.1)

[31]

Default

MergeAlign (n.f.)

[76]

Default (#)

Noisy (v.1.5.12)

[77]

Default

PSAR-Align (v.1.0)

[78]

Default

TCS (T-COFFEE) (v.11.00.8cbe486)

[79]

(3) TCS, TCS_original, TCS_FM

TrimAl (v.1.4)

[30]

(6) TrimAl Default, TrimAl ‘automated1’, TrimAl ‘gappyout’, TrimAl ‘strictplus’, TrimAl ‘strict’, TrimAl ‘compareset’ (#)

WeaveAlign (v.1.2.1)

[20]

Default (#)

Stage 5 (PE)

IQ-TREE (v.1.6.2)

[80, 81]

(15) IQ-TREE DNA, IQ-TREE DNA (DEG), IQ-TREE DNA (RY), IQ-TREE CODON, IQ-TREE NT2AA. Each case is available for Default and Standard / UFBoot [81] Bootstraps

MPBoot (v.1.1.0)

[82]

(2) MPBoot DNA. Each case is available for Default and “UFBoot” Bootstraps

Ninja (v.1.2.2)

[83]

Default

SMS (v.1.8.1)

[84]

(4) AIC + NNI, AIC + SPR, BIC + NNI, BIC + SPR

Degen (v.1.4) (*)

[85, 86]

Default

RYcode (v.1.0.0) (*)

This work

Default

Stage 6 (PCC)

CONSEL (v.1.20)

[87]

Default (includes makermt, consel and catpv)

TreeCmp (v.1.1)

[88]

Default

  1. Legend: (Number) – Algorithms Implemented column, where present, indicates the total number of algorithms implemented. (n.f.) – not found. (*) – Integrated as part of Stage 5 IQ-TREE algorithms DNA (DEG) and DNA (RY). (#) – Stage 4 consensus algorithms. DNA (nucleotide coding), DEG (degeneracy coding), RY (puRine and pirYmidine coding), NT2AA (translated – amino acid coding). AIC (Akaike Information Criterion) [89], BIC (Bayesian Information Criterion) [90], NNI (Nearest-Neighbor Interchange), SPR (Subtree Prunning and Regrafting). dN (non-synonymous distance), dS (synonymous distance). Listed software versions (see also Additional file 2: Figure S7) are only for reference of working cases and can be replaced by newer ones