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Table 3 Boolean Functions and Description of LPS Stimulated M1 Activation Network. IS: intermediate state

From: Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles

Child nodeParent nodeValidationAttributionWeights from LP
FGF-9(K + 1)N/AInput- [26]InputN/A
GM-CSF(K + 1)\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K) & MCP-5(K)IFN- γ: String [27], MCP-5 [28,29,30]:Output(− 180, 185)
KC-GRO(K + 1)IL-10(K)&\( \overline{\mathrm{MCP}-5} \) (K)IL-10: String
MCP-5: String
IS(5.45, −5.82)
IFN-γ(K + 1)SCF(K) || IFN- γ (K)IFN-γ [31, 32]:
SCF [33, 34]:
IS(1170)
IP-10(K + 1)IL-10(K)& MCP-5 (K)MCP-5: String [33, 35, 36],
IL-10 [33, 35, 37] [38]:
Output(68,100, 85,000)
IL-1α(K + 1)Lymphotactin(K)KEGGIS(787000)
IL-2(K + 1)(\( \overline{\mathrm{KC}-\mathrm{GRO}} \) (K)&\( \overline{\mathrm{MIP}-2} \) K)) ||
(KC-GRO(K)&\( \overline{\mathrm{Rantes}} \) (K))
KC-GRO: String [39, 40],
MIP-2: String [41],
RANTES: [33, 42, 43]
Output(34.7,-27, − 33.8)
IL-3(K + 1)SCF(K)SCF: StringIS(302)
IL-4(K + 1)N/AInput [44]:InputN/A
IL-6(K + 1)IL-1α(K) &\( \overline{\mathrm{Rantes}} \) (K)IL-1α: String [45, 46],
RANTES: String
Output(3840, − 4840)
IL-7(K + 1)MIP-1β(K)MIP-1β: String [47],Output(10)
IL-10(K + 1)\( \overline{\mathrm{IL}-4} \) (K) &Lymphotactin(K)IL-4: String [48] [49],
Lymphotactin: String
IS(− 64,700, 48,600)
IL-11(K + 1)FGF-9 (K)FGF-9-StringIS(6190)
IL-12p70(K + 1)MCP-5(K)KEGGOutput5.6
IL-17A (K + 1)MCP-5(K)KEGGOutput(0.555)
Lympho-
tactin(K + 1)
\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K)IFN- γ: String [50],IS− 1675
MIP-1β(K + 1)IL-3(K) || IL-11(K))IL-3: String
IL-11: String
IS(44,800, 41,600)
MIP-2(K + 1)IL-10(K)& \( \overline{\mathrm{MIP}-1\upbeta} \) (K)IL-10: String [51]
MIP-1β: String [52]
IS(7880, − 10,400)
MCP-1(K + 1)\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K)IFN- γ: String [53]IS(− 5090)
MCP-3(K + 1)(IL-4(K)& (FGF-9(K))||
(\( \overline{\mathrm{FGF}-9} \)(K) & \( \overline{\mathrm{Rantes}} \) (K)))
FGF-9 [26]:
IL-4 [54]:
Rantes: String
IS(27,600,
22,800,
− 27,400)
MCP-5(K + 1)Lymphotactin(K) &MCP-1(K)Lymphotactin: StringIS(5840, − 4590)
OSM(K + 1)IL-10(K) & MIP-1β(K)IL-10 [55]:
MIP-1β: String
Output(6.45, 6.19)
SCF(K + 1)\( \overline{\mathrm{IL}-1\upalpha} \) (K)IL-1α [56]:IS(− 70,800)
RANTES(K + 1)\( \overline{\mathrm{MCP}-3} \) (K)KEGGIS(304)
TNF-α(K + 1)\( \overline{\mathrm{IL}-1\upalpha} \) (K)IL-1α: String [57]Output(− 1.37)
VEGF-A(K + 1)\( \overline{\mathrm{MCP}-5} \) (K)MCP-5 [58]:Output(− 17,850)