Table 3 Boolean Functions and Description of LPS Stimulated M1 Activation Network. IS: intermediate state

FGF-9(K + 1)

N/A

Input- [26]

Input

N/A

GM-CSF(K + 1)

\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K) & MCP-5(K)

IFN- γ: String [27], MCP-5 [28,29,30]:

Output

(− 180, 185)

KC-GRO(K + 1)

IL-10(K)&\( \overline{\mathrm{MCP}-5} \) (K)

IL-10: String

MCP-5: String

IS

(5.45, −5.82)

IFN-γ(K + 1)

SCF(K) || IFN- γ (K)

IFN-γ [31, 32]:

SCF [33, 34]:

IS

(1170)

IP-10(K + 1)

IL-10(K)& MCP-5 (K)

MCP-5: String [33, 35, 36],

IL-10 [33, 35, 37] [38]:

Output

(68,100, 85,000)

IL-1α(K + 1)

Lymphotactin(K)

KEGG

IS

(787000)

IL-2(K + 1)

(\( \overline{\mathrm{KC}-\mathrm{GRO}} \) (K)&\( \overline{\mathrm{MIP}-2} \) K)) ||

(KC-GRO(K)&\( \overline{\mathrm{Rantes}} \) (K))

KC-GRO: String [39, 40],

MIP-2: String [41],

RANTES: [33, 42, 43]

Output

(34.7,-27, − 33.8)

IL-3(K + 1)

SCF(K)

SCF: String

IS

IL-4(K + 1)

N/A

Input [44]:

Input

N/A

IL-6(K + 1)

IL-1α(K) &\( \overline{\mathrm{Rantes}} \) (K)

IL-1α: String [45, 46],

RANTES: String

Output

(3840, − 4840)

IL-7(K + 1)

MIP-1β(K)

MIP-1β: String [47],

Output

(10)

IL-10(K + 1)

\( \overline{\mathrm{IL}-4} \) (K) &Lymphotactin(K)

IL-4: String [48] [49],

Lymphotactin: String

IS

(− 64,700, 48,600)

IL-11(K + 1)

FGF-9 (K)

FGF-9-String

IS

(6190)

IL-12p70(K + 1)

MCP-5(K)

KEGG

Output

5.6

IL-17A (K + 1)

MCP-5(K)

KEGG

Output

(0.555)

Lympho-

tactin(K + 1)

\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K)

IFN- γ: String [50],

IS

− 1675

MIP-1β(K + 1)

IL-3(K) || IL-11(K))

IL-3: String

IL-11: String

IS

(44,800, 41,600)

MIP-2(K + 1)

IL-10(K)& \( \overline{\mathrm{MIP}-1\upbeta} \) (K)

IL-10: String [51]

MIP-1β: String [52]

IS

(7880, − 10,400)

MCP-1(K + 1)

\( \overline{\mathrm{IFN}-\mathrm{y}} \) (K)

IFN- γ: String [53]

IS

(− 5090)

MCP-3(K + 1)

(IL-4(K)& (FGF-9(K))||

(\( \overline{\mathrm{FGF}-9} \)(K) & \( \overline{\mathrm{Rantes}} \) (K)))

FGF-9 [26]:

IL-4 [54]:

Rantes: String

IS

(27,600,

22,800,

− 27,400)

MCP-5(K + 1)

Lymphotactin(K) &MCP-1(K)

Lymphotactin: String

IS

(5840, − 4590)

OSM(K + 1)

IL-10(K) & MIP-1β(K)

IL-10 [55]:

MIP-1β: String

Output

(6.45, 6.19)

SCF(K + 1)

\( \overline{\mathrm{IL}-1\upalpha} \) (K)

IL-1α [56]:

IS

(− 70,800)

RANTES(K + 1)

\( \overline{\mathrm{MCP}-3} \) (K)

KEGG

IS

(304)

TNF-α(K + 1)

\( \overline{\mathrm{IL}-1\upalpha} \) (K)

IL-1α: String [57]

Output

VEGF-A(K + 1)

\( \overline{\mathrm{MCP}-5} \) (K)

MCP-5 [58]:

Output

(− 17,850)