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Table 5 Boolean Functions and Description of IL-4 Stimulated M2a Activation Network. The * symbol denotes a non-validated link from public databases or literature

From: Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles

Child nodeParent nodeValidationAttributionLP Weights
FGF-9(K + 1)(\( \overline{\mathrm{MIP}-2} \) *(k)&\( \overline{\mathrm{Vegf}-\mathrm{A}} \) (k)) ||
(MIP-2(k) & VEGF-A(k)) ||
(\( \overline{\mathrm{MIP}-2} \) (k) &Lymphotactin(k))
VEGF-A: String [61] [62, 63],
Lymphotactin [64]:
IS(89.6, 87, − 82)
GM-CSF(K + 1)\( \overline{\mathrm{MCP}-1} \) (K) || SCF(K)MCP-1: String [65, 66],
SCF: String
Output(2.75, −3.23)
IFN- γ (K + 1)MIP-2(k) || \( \overline{\mathrm{Vegf}-\mathrm{A}} \) (k)MIP-2: String [67, 68],
VEGF-A: String
IS(34, − 31.7)
IP-10(K + 1)VEGF-A(K)[69, 70]IS121
IL-1α(K + 1)N/AInput [71]:InputN/A
IL-2(K + 1)MCP-3(K)StringIS92.7
IL-3(K + 1)MCP-3(K)[72, 73]Output41.9
IL-4(K + 1)MCP-1(K)String [74,75,76],Output151
IL-6(K + 1)Lymphotactin(K)[77]Output58.7
IL-7(K + 1)IL-1α(K) & MCP-5* (K)IL-1α: [78]Output(−0.9, − 1)
IL-10(K + 1)VEGF-A(K)[79]IS− 296
IL-12p70(K + 1)Lymphotactin(K)KEGGOutput0.557
IL-17A(K + 1)MCP-3(K)MCP-3 [80, 81]:Output(.34)
Lympho-tactin(K + 1)IL-1α (K) & MCP-5 (K)[82]IS(192, − 159)
MIP-1ϐ(K + 1)IL-1α(K) & MCP-1(K))IL-1α: String [83] [84]
MCP-1: String,
[85] [86]
IS(− 6490, 6650)
MIP-2(K + 1)MCP-3(K)& MCP-5(K)MCP-3 [87]:
MCP-5: String [87],
IS(816, − 1160)
MCP-1(K + 1)\( \overline{\mathrm{IL}-2} \) (K) & \( \overline{\mathrm{MIP}-1\upbeta} \) MIP-1ϐ(K)IL-2 [88, 89]:
MIP-1β:String [85] [86],,
IS(− 6150, − 6520)
MCP-3(K + 1)IFN- γ (K) &MCP-1(K)IFN- γ: String [90, 91],
MCP-1: String [92],
IS(−15,900, 16,800)
MCP-5(K + 1)SCF(K) || \( \overline{\mathrm{VEGF}-\mathrm{A}} \) (K)SCF [93]:
VEGF-A: KEGG
IS(1300, − 1140)
OSM(K + 1)MCP-1(K)String [94, 95],Output1.11
SCF(K + 1)FGF-9(K)* & IL-10(K)IL-10 [96, 97]:IS(12,700, − 14,400)
TIMP-1(K + 1)Lymphotactin*(K)Not validatedOutput1.19
TNF-α(K + 1)IL-2(K)String [98, 99],Output−0.188
VEGF-A(K + 1)MCP-5(K) & SCF(K)MCP-5:String
SCF: String [100, 101],
IS(−13,400, 13,300)