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Table 6 Boolean Functions and Description of IL-10 Stimulated M2c Activation Network. The * symbol denotes a non-validated link from public databases or literature

From: Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles

Child nodeParent nodeReferencesAttributionLP Weights
FGF-9(K + 1)MIP-1β*(K)Not ValidatedIS13
GM-CSF(K + 1)\( \overline{\mathrm{IP}-10} \) (K) & \( \overline{\mathrm{IL}-2} \) (K) & IL-4(K) & IL-10(K)IL-2: String [102],
IL-4: String [102], [103]
IL-10: [104, 105]
Output(−0.83, − 0.73, 0.73, 0.75)
IFN-γ(K + 1)IL-1α(K) & SCF(K)IL-1α: String
SCF: String
IS(− 18,20)
IP-10(K + 1)MCP-1(K) & MCP-3(K)MCP-3: String MCP-1: String [106],IS(− 4470, 4050)
IL-1α(K + 1)IL-11(K) & MCP-3(K)IL-11: String
MCP-3: String
IS(− 699, 609)
IL-2(K + 1)IL-10(K) & \( \overline{\mathrm{IL}-11} \) (K)IL-11: String
IL-10: String,
IS(5.62, −6.42)
IL-3(K + 1)(FGF-9 (K) & \( \overline{\mathrm{IL}-1\mathrm{a}} \) (K) & \( \overline{\mathrm{MIP}-1} \) (K) & MCP-3(K)FGF-9: String,
MCP-3: [72]
MCP-1: [107]
Output(7.16, − 7.99, − 8.86, 8.68)
IL-4(K + 1)IL-10(K)String, [48, 108]IS41.6
IL-6(K + 1)IL-1α(K) & MIP-1ϐ(K) & \( \overline{\mathrm{MIP}-2} \) (K) & \( \overline{\mathrm{VEGF}-\mathrm{A}} \) (K)MIP-2: String, VEGF-A: String
IL-1α: [45, 46] MIP-1ϐ [109, 110]:
Output(2.26, 2.09, − 2.4, − 2.04)
IL-7(K + 1)MCP-3(K)StringOutput0.476
IL-10(K + 1)MCP-3(K)StringIS3330
IL-11(K + 1)IL-1α(K)String [111, 112],IS−78.1
IL-12p70(K + 1)MCP-3 (K) || \( \overline{\mathrm{SCF}} \)(K)MCP-3 [113]: SCF: [114]Output(1.34, −1.38)
IL-17A(K + 1)\( \overline{\mathrm{MCP}-1} \) (K) || MCP-3(K)MCP-1: String [115,116,117,118],
MCP-3: String [80],
Output(−0.236, 0.19)
Lympho-tactin(K + 1)SCF(K)StringIS39
MIP-1β(K + 1)IL-11(K)StringIS−16,100
MIP-2(K + 1)SCF(K)String [119],IS2420
MCP-1(K + 1)MIP-1β(K) & SCF(K)MIP-1β: String [85, 86],
SCF: String [120, 121] [,122],
IS(2050,1920)
MCP-3(K + 1)IFN- γ (K)IFN- γ: String [90, 91],IS1410
MCP-5(K + 1)\( \overline{\mathrm{SCF}} \) (K)SCF [93]:IS−728
OSM(K + 1)MIP-1β(K)MIP-1β: String [123,124,125],Output0.186
SCF(K + 1)IL-11(K) & MCP-5(K)IL-11: String [126],
MCP-5 [93]:
State(14,700, − 18,000)
TNF-α(K + 1)IP-10(K)IP-10: String [127],Output0.156
VEGF-A(K + 1)Lymphotactin (K) || \( \overline{\mathrm{MCP}-5} \) (K)MCP-5: StringOutput(19,200, −24,100)