Table 6 Boolean Functions and Description of IL-10 Stimulated M2c Activation Network. The * symbol denotes a non-validated link from public databases or literature

FGF-9(K + 1)

MIP-1β*(K)

Not Validated

IS

13

GM-CSF(K + 1)

\( \overline{\mathrm{IP}-10} \) (K) & \( \overline{\mathrm{IL}-2} \) (K) & IL-4(K) & IL-10(K)

IL-2: String [102],

IL-4: String [102], [103]

IL-10: [104, 105]

Output

(−0.83, − 0.73, 0.73, 0.75)

IFN-γ(K + 1)

IL-1α(K) & SCF(K)

IL-1α: String

SCF: String

IS

(− 18,20)

IP-10(K + 1)

MCP-1(K) & MCP-3(K)

MCP-3: String MCP-1: String [106],

IS

(− 4470, 4050)

IL-1α(K + 1)

IL-11(K) & MCP-3(K)

IL-11: String

MCP-3: String

IS

(− 699, 609)

IL-2(K + 1)

IL-10(K) & \( \overline{\mathrm{IL}-11} \) (K)

IL-11: String

IL-10: String,

IS

(5.62, −6.42)

IL-3(K + 1)

(FGF-9 (K) & \( \overline{\mathrm{IL}-1\mathrm{a}} \) (K) & \( \overline{\mathrm{MIP}-1} \) (K) & MCP-3(K)

FGF-9: String,

MCP-3: [72]

MCP-1: [107]

Output

(7.16, − 7.99, − 8.86, 8.68)

IL-4(K + 1)

IL-10(K)

String, [48, 108]

IS

41.6

IL-6(K + 1)

IL-1α(K) & MIP-1ϐ(K) & \( \overline{\mathrm{MIP}-2} \) (K) & \( \overline{\mathrm{VEGF}-\mathrm{A}} \) (K)

MIP-2: String, VEGF-A: String

IL-1α: [45, 46] MIP-1ϐ [109, 110]:

Output

(2.26, 2.09, − 2.4, − 2.04)

IL-7(K + 1)

MCP-3(K)

String

Output

0.476

IL-10(K + 1)

MCP-3(K)

String

IS

3330

IL-11(K + 1)

IL-1α(K)

String [111, 112],

IS

−78.1

IL-12p70(K + 1)

MCP-3 (K) || \( \overline{\mathrm{SCF}} \)(K)

MCP-3 [113]: SCF: [114]

Output

(1.34, −1.38)

IL-17A(K + 1)

\( \overline{\mathrm{MCP}-1} \) (K) || MCP-3(K)

MCP-1: String [115,116,117,118],

MCP-3: String [80],

Output

(−0.236, 0.19)

Lympho-tactin(K + 1)

SCF(K)

String

IS

39

MIP-1β(K + 1)

IL-11(K)

String

IS

MIP-2(K + 1)

SCF(K)

String [119],

IS

2420

MCP-1(K + 1)

MIP-1β(K) & SCF(K)

MIP-1β: String [85, 86],

SCF: String [120, 121] [,122],

IS

(2050,1920)

MCP-3(K + 1)

IFN- γ (K)

IFN- γ: String [90, 91],

IS

1410

MCP-5(K + 1)

\( \overline{\mathrm{SCF}} \) (K)

SCF [93]:

IS

−728

OSM(K + 1)

MIP-1β(K)

MIP-1β: String [123,124,125],

Output

0.186

SCF(K + 1)

IL-11(K) & MCP-5(K)

IL-11: String [126],

MCP-5 [93]:

State

(14,700, − 18,000)

TNF-α(K + 1)

IP-10(K)

IP-10: String [127],

Output

0.156

VEGF-A(K + 1)

Lymphotactin (K) || \( \overline{\mathrm{MCP}-5} \) (K)

MCP-5: String

Output

(19,200, −24,100)