Fig. 2

Impact of algorithm initialization of RefFreeEWAS method performance. `A MAE` is shown for 10 D matrices (mean value of 10 random noises applied on D) computed from 10 random A. Each color represents a different simulated A. Error bars represent standard deviation on 10 random noises. The following parameters were used to simulate D: K = 5, α₀ = 1, ε = 0.2, G = 1 and n = 100). Euclidean corresponds to RefFreeEWAS::RefFreeCellMixInitialize function applied with the default parameter dist.method = “euclidean”. Manhattan corresponds to RefFreeEWAS::RefFreeCellMixInitialize function applied with the parameter dist.method = “manhattan”. Real T corresponds to RefFreeEWAS::RefFreeCellMix used with the parameter mu0 = real_T, with real_T the matrix composed of the 5 cell types used to simulate D. SVD corresponds to RefFreeEWAS::RefFreeCellMixInitializeBySVD function with default parameters