Fig. 5

Impact of K selection on algorithm performance. `A MAE` is shown for D matrices (mean value of 10 random noises applied on D) computed from 1 random A. Each color represents a different method. Error bars represent standard deviation on 10 random noise realizations. RFE stands for RefFreeEWAS, MDC for MeDeCom and EDec for EDec stage 1, each method was applied with various imposed K parameters (from 2 to 7). a The following parameters were used to simulate D: K = 3, α₀ = 1, ε = 0.2, G = 1 and n = 100. RFE and MDC methods were run after removal of confounding probes (between 22,517 and 22,624 remaining probes), EDec was run on informative loci, as recommended by the method’s authors (614 remaining probes). b The following parameters were used to simulate D: K = 5, α₀ = 1, ε = 0.2, G = 1 and n = 100. RFE and MDC methods were run after removal of confounding probes (between 22,551 and 22,602 remaining probes), EDec was run on informative loci, as recommended by the method’s authors (614 remaining probes)