Fig. 1

Schematic of the mutual repression network model with negative autoregulation. Wiring diagram of the mutual repression network with negative autoregulation (MRN-NA) model. The added negative autoregulation reactions that regulate the protein synthesis of y(2) and y(3) are highlighted in red. All reaction rate constants k and dissociation constants K are listed in Tables 1 and 2. In this work, the MRN-NA is compared to the previously published MRN [12] that is identical with the exception of the negative autoregulation loops. In addition, a simplified wiring diagram is shown