Fig. 5

Mean first passage time (MFPT) analysis. a The logarithmic MFPTs of the lower and upper steady states of y(2) (T_L and T_U) and y(3) (T_L and T_U) are shown for the MRN and MRN-NA models as a function of the Hill coefficient n at dissociation constants K(2) = K(4) = 15. b The logarithmic MFPTs of the lower and upper steady states of y(2) and y(3) denoted as above are shown for the MRN and MRN-NA as a function of the dissociation constant K(2) = K(4) at the Hill coefficient n = 3. c The logarithmic MFPTs of the lower and upper steady states of y(2) and y(3) denoted as above are shown for the MRN-NA as a function of the negative autoregulation constants k(9) = k(10) at the dissociation constants K(2) = K(4) = 15 and Hill coefficient n = 3