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Table 2 TERT regulators of melanoma samples with (mut) and without (wt) TERT promoter mutation

From: Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach

Regulators in mut

P-value*

Regulators in wt

P-value**

AR

3.97 E-37

HMGA2

1.05 E-16

E2F1

3.00 E-29

HIF.1

1.03 E-15

JUND

2.86 E-25

RUNX2

2.88 E-12

SMARCB1

1.85 E-15

TAL1

1.54 E-09

ETS1

4.46 E-13

ESR2

3.92 E-09

SIN3AK20

1.42 E-06

AP-2

3.28 E-06

REST

3.64 E-06

MITF

2.59 E-05

MAZ

7.85 E-06

WT1

2.80 E-05

E2F2

9.20 E-05

SMAD3

5.76 E-05

TAF1

1.36 E-04

TFAP2D

2.78 E-04

BCL11A

4.31 E-04

PAX8

6.04 E-04

MYB

4.73 E-04

GRHL2

7.16 E-04

  

TP53

1.21 E-03

  

TCF7

1.68 E-03

  

MZF1

3.44 E-03

  

TFAP2C

3.68 E-03

  

NR2F2

7.96 E-03

  1. *indicates if a regulator was significantly more often selected in the samples with TERT promoter mutation compared to the wildtype
  2. **indicates if a regulator was significantly more often selected in the wildtype compared to the TERT promoter mutated samples