Fig. 1From: ZDOG: zooming in on dominating genes with mutations in cancer pathwaysIllustration of the dominator tree model. A toy signalling pathway example (left) containing protein components A to I and R, where R is the signal entry point, and its dominator tree (right). Because of the right feedback loop between H and F, only the protein R completely controls F and H, indicating that a mutation occurring in R may affect the functions of F and H more than a mutation in any other component in the pathwayBack to article page